Cyclic Nucleotide-Regulated Ion Channels: From Light Sensing to Pace Keeping
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چکیده
The cyclic nucleotide-regulated ion channels are a heterogeneous superfamily of different ion channels that share common membrane topology and pore structure and display a cyclic nucleotide-binding domain in their C-terminal region. Members of this superfamily include cyclic nucleotide-gated (CNG) cation channels, hyperpolarizationactivated cyclic nucleotide-gated (HCN) cation channels and also several members of the voltage-dependent K channels such as the K V 10 (eag) and the K V 11 (erg) subfamilies. Channel regulation by cyclic nucleotides has been largely studied in the context of the CNG and HCN groups and will be the subject of this brief review. Noemí Bronstein-Sitton, Ph.D.
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